Contrave 8/90
$340.00
How to Take Contrave: Dosing Schedule
Contrave requires a gradual dose escalation to help your body adjust to the medication. Do not cut, chew, or crush the tablets—swallow them whole with a glass of water .
| Week | Morning Dose | Evening Dose | Total Daily Dose |
|---|---|---|---|
| Week 1 | 1 tablet | None | 8 mg/90 mg |
| Week 2 | 1 tablet | 1 tablet | 16 mg/180 mg |
| Week 3 | 2 tablets | 1 tablet | 24 mg/270 mg |
| Week 4 and beyond | 2 tablets | 2 tablets | 32 mg/360 mg |
Contrave Product Overview
Contrave 8/90 is a prescription medication specifically designed for chronic weight management in adults. Each extended-release tablet contains a unique combination of two active ingredients: 8 mg Naltrexone HCl and 90 mg Bupropion HCl .
Unlike traditional weight loss supplements, Contrave works on two distinct areas of the brain—the appetite regulatory center (hypothalamus) and the reward system (mesolimbic dopamine circuit)—to help control food intake and reduce food cravings .
Please Note: Contrave is a prescription medication. You must have a valid prescription from a licensed healthcare provider to purchase this product from PillsUnit.com.
| Product Feature | Details |
|---|---|
| Strength | Naltrexone HCl 8 mg / Bupropion HCl 90 mg |
| Form | Extended-release tablets |
| Dosage | Titration schedule: Weeks 1-4 (see dosing guide below) |
| Maintenance Dose | 2 tablets twice daily (32 mg/360 mg per day) |
| Storage | Store below 25°C (77°F); do not freeze |
| Prescription Required | Yes |
What is Contrave?
Contrave is an FDA-approved combination medication that brings together two well-studied ingredients:
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Naltrexone: An opioid antagonist that works on the brain’s reward system
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Bupropion: A relatively weak inhibitor of dopamine and norepinephrine reuptake
Together, these ingredients work synergistically to help you feel fuller longer and reduce food cravings, making it easier to stick to a reduced-calorie diet and increased physical activity plan .
Who is Contrave For?
Contrave is indicated for adults with:
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BMI of 30 kg/m² or greater (obese), OR
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BMI of 27 kg/m² or greater (overweight) with at least one weight-related condition such as:
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Type 2 diabetes
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High blood pressure (hypertension)
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High cholesterol (dyslipidemia)
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Limitations of Use:
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The effect of Contrave on cardiovascular morbidity and mortality has not been established
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Safety and effectiveness in combination with other weight loss products (prescription, OTC, or herbal) have not been established
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Not recommended for children under 18 years
How to Take Contrave: Dosing Schedule
Contrave requires a gradual dose escalation to help your body adjust to the medication. Do not cut, chew, or crush the tablets—swallow them whole with a glass of water .
| Week | Morning Dose | Evening Dose | Total Daily Dose |
|---|---|---|---|
| Week 1 | 1 tablet | None | 8 mg/90 mg |
| Week 2 | 1 tablet | 1 tablet | 16 mg/180 mg |
| Week 3 | 2 tablets | 1 tablet | 24 mg/270 mg |
| Week 4 and beyond | 2 tablets | 2 tablets | 32 mg/360 mg |
Important Administration Tips:
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Take your morning and evening doses approximately 12 hours apart
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Can be taken with or without food, but avoid high-fat meals as they can significantly increase medication exposure
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If you miss a dose, skip it and take your next scheduled dose—do not double up
How Well Does Contrave Work?
Clinical studies have shown that Contrave, combined with diet and exercise, can lead to significant weight loss:
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Most participants experienced noticeable weight loss after 4 weeks of treatment
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After 12 weeks at the maintenance dose, your doctor will evaluate your progress
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If you haven’t lost at least 5% of your baseline body weight by week 12, Contrave is unlikely to work for you and treatment should be discontinued
According to a 2024 systematic review, the naltrexone-bupropion combination results in more initial and sustained weight loss than bupropion alone .
Important Safety Information
Boxed Warning: Risk of Suicidal Thoughts and Behaviors
Contrave contains bupropion, which carries a boxed warning (the most serious warning from the FDA) about an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults .
Watch for these symptoms and contact your doctor immediately if you experience:
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New or worsening depression, anxiety, or agitation
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Panic attacks
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Difficulty sleeping
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Irritability
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Aggressive or impulsive behavior
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Thoughts of self-harm or suicide
Common Side Effects
Most side effects are mild and often improve as your body adjusts. The most common include (occurring in ≥5% of patients):
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Nausea or vomiting
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Constipation or diarrhea
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Headache
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Dizziness
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Dry mouth
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Insomnia or sleep disruptions
Serious Side Effects (Seek medical attention)
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Seizures (risk increases if you exceed recommended dose)
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Increased blood pressure or heart rate
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Allergic reactions (rash, itching, facial swelling)
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Liver problems
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Eye pain or vision changes (possible closed-angle glaucoma)
Who Should NOT Take Contrave?
Do not use Contrave if you:
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Have uncontrolled high blood pressure
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Have a seizure disorder or history of seizures
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Have an eating disorder (bulimia or anorexia nervosa)
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Are undergoing sudden discontinuation of alcohol, benzodiazepines, or sedatives
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Are taking opioids or undergoing opioid withdrawal
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Have taken MAO inhibitors within the past 14 days
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Are pregnant, planning to become pregnant, or breastfeeding
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Have severe liver or kidney disease
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Are taking other medications containing bupropion or naltrexone
Drug Interactions
Contrave may interact with many medications. Tell your doctor if you take:
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Other antidepressants or antipsychotics
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Blood pressure medications (especially metoprolol)
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Heart rhythm medications (propafenone, flecainide)
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Parkinson’s disease medications (levodopa, amantadine)
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HIV medications (efavirenz, ritonavir)
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Blood thinners (clopidogrel, ticlopidine)
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Opioid painkillers (codeine, morphine, methadone)
Special Populations
Pregnancy and Breastfeeding
Do not use Contrave if you are pregnant. Weight loss offers no benefit during pregnancy and may harm your baby. Contrave passes into breast milk and is not recommended while breastfeeding .
Kidney or Liver Impairment
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Moderate to severe kidney impairment: Maximum 1 tablet twice daily
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End-stage kidney disease: Not recommended
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Moderate liver impairment: Maximum 1 tablet twice daily
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Severe liver impairment: Not recommended
Why Buy Contrave from PillsUnit.com?
At PillsUnit.com, we prioritize your health and safety:
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Authentic Medication: All products are sourced from licensed, reputable manufacturers
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Prescription Required: We verify all prescriptions to ensure you’re taking medication appropriate for your health needs
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Discreet Shipping: Your privacy matters—orders arrive in unmarked packaging
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Secure Transactions: Your personal and payment information is protected with industry-standard encryption
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Customer Support: Our knowledgeable team is available to answer your questions
How to Order
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Upload your prescription during checkout (or email it to us after ordering)
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Complete your purchase with our secure payment system
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We verify your prescription with our licensed pharmacy partners
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Your order ships discreetly to your door
Prescription Required: Contrave 8/90 is a prescription medication. By ordering, you certify that you have a valid prescription from a licensed healthcare provider.
Frequently Asked Questions
How long does it take to see results with Contrave?
Most patients begin seeing weight loss within the first 4 weeks, but your doctor will evaluate your progress at 12 weeks to determine if continued treatment is right for you .
Can I take Contrave with other weight loss products?
No. The safety and effectiveness of Contrave with other weight loss products (prescription, OTC, or herbal) has not been established .
What happens if I miss a dose?
If you miss a dose, skip it and take your next dose at the regularly scheduled time. Do not take extra medicine to make up for the missed dose .
Is Contrave a controlled substance?
No, Contrave is not classified as a controlled substance, but it does require a prescription due to its potential side effects and drug interactions.
How should I store Contrave?
Store at room temperature (below 25°C/77°F) in a dry place. Do not freeze. Keep out of reach of children .
Order Contrave 8/90 Today
Take the next step in your weight management journey with Contrave from PillsUnit.com. When combined with a reduced-calorie diet and increased physical activity, Contrave can help you achieve meaningful, sustainable weight loss.
Price: Call for current pricing and available discounts
Shipping: Free standard shipping on all prescription orders
Delivery: 3-5 business days (expedited options available)
Medical Disclaimer: The information provided on this page is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment before starting a new medication.
References:
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Contrave Prescribing Information. FDA
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Healthline. Guide to Naltrexone-Bupropion for Weight Management
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Optum. Contrave Dosage: A Detailed Guide
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Pharmacy Times. Daily Medication Pearl: Naltrexone HCl and Bupropion HCl (Contrave)
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NPS MedicineWise. Contrave 8/90 Consumer Medicine Information
Important Safety Information
CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.
While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes.
Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping.
CONTRAVE is not approved for use in children under the age of 18.
Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE.
Tell your healthcare provider about all of your medical conditions, including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
CONTRAVE may cause serious side effects, including:
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Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away.
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Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.
Get emergency medical help right away if you take opioids and you:
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have trouble breathing
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become very drowsy with slowed breathing
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have slow, shallow breathing
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feel faint, very dizzy, confused, or have unusual symptoms
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Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery.
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Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.
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Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE.
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Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem.
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Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again.
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Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.
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Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE.
The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE. contrave australia
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