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Opana 5mg (oxymorphone hydrochloride) is a licensed medicine available only on prescription, but note that as of 2025, Opana and its generics have been discontinued in many markets, including potential UK unavailability – always verify with a prescriber. Our UK-registered prescribers can issue a private prescription after a quick, free online consultation if clinically appropriate, or recommend alternatives like oxycodone. Opana pill
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acts as a potent mu-opioid agonist, binding to receptors in the brain and spinal cord to alter pain perception and provide relief lasting 4-6 hours. Due to its high abuse potential (Schedule II controlled substance), it is recommended for short-term use only in opioid-tolerant patients, with close monitoring to avoid dependence or overdose. Opana pill
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Opana pill WARNING:
OPANA ER contains oxymorphone, which is a morphine-like opioid agonist and a Schedule II controlled substance, with an abuse liability similar to other opioid analgesics.
Oxymorphone can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing OPANA ER in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.
OPANA ER is an extended-release oral formulation of oxymorphone indicated for the management of moderate to severe pain when a continuous, around-the-clock opioid analgesic is needed for an extended period of time.
OPANA ER is NOT intended for use as a prn analgesic. Opana pill
OPANA ER TABLETS are to be swallowed whole and are not to be broken, chewed, dissolved, or crushed. Taking broken, chewed, dissolved, or crushed OPANA ER TABLETS leads to rapid release and absorption of a potentially fatal dose of oxymorphone.
Patients must not consume alcoholic beverages, or prescription or nonprescription medications containing alcohol, while on OPANA ER therapy. The co-ingestion of alcohol with OPANA ER may result in increased plasma levels and a potentially fatal overdose of oxymorphone.
- Physical: Drowsiness, dizziness, nausea, vomiting, and severe constipation.
- Mental: Confusion, headache, or a “floating feeling”.
- Serious Risks: The most dangerous risk is respiratory depression (slow or shallow breathing), which can be fatal, especially if combined with alcohol or other sedatives.
- Benzodiazepines (e.g., Xanax, Valium).
- Other opioids or CNS depressants.
- MAO inhibitors.




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